Royal Air Force Typhoon jets have operated alongside French aircraft in a combined operation on an subterranean weapons facility in Syrian territory operated by the IS group, as stated by the UK's MoD.
The site, identified by surveillance, was believed to be containing munitions and bombs, the release indicated, and was situated in hills just above the ancient city of Palmyra in central Syria.
"The RAF jets utilized Paveway IV guided bombs to hit a several entry passages leading to the depot... initial indications suggest the strike was effective," the MoD said.
There was no indication of any civilian impact in the attack on Saturday evening and each participating jet made a safe return, the MoD added.
The Typhoon fighters were supported by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as Daesh - established militant control over parts of Iraq and Syria until 2019.
"This action demonstrates British leadership, and resolve to work closely with our partners, to eradicate any revival of IS and their violent and radical beliefs in the Middle East," the British Defence Secretary the minister remarked.
UK warplanes have carried out surveillance missions over Syria to "deter any attempted resurgence" of Islamic State after its defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I want to thank all the members of our armed forces participating in this strike for their expertise and their bravery," he said. "They were part of numerous British personnel stationed over the holidays. This operation, to eliminate militants who threaten our safety, highlights how British military are always on standby, all year round, protecting the UK within its borders and strong abroad."
During December, the American forces executed what it called a "major assault" on Daesh sites in the country, subsequent to an assault resulted in the deaths of two US servicemembers and a civilian linguist in Palmyra.
The United Nations reports Daesh still boasts between 5,000 and 7,000 fighters in Iraq and Syria.